Sample : Chlorthalidone
Column : Shodex ORpak CDB-453 HQ (4.6mmID*150mm)
Eluent : (1.1% CH3COOH + 0.2M NaCl)/CH3CN=90/10
Flow rate : 0.2mL/min
Detector : UV(300nm), ORD
Column temp. : 10°C
Chlorthalidone (1)
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Optical rotation of each peak can be monitored by using a combination of an optical rotation detector (ORD) and ORpak CDB-453 HQ (a column for chiral separation). A positive peak shows dextrorotation, while a negative peak shows levorotation. The results of the analysis of chlorthalidone, a diuretic, using a UV detector and an optical rotation detector is shown.
Category: Chiral Compounds