Statins are a group of drugs used to lower cholesterol level by inhibiting HMG-CoA reductase. Seven statins were simultaneously analyzed by LC/MS method using a polymer-based reversed phase column, ODP2 HP-2B.
Sample : 100ng/mL each, 5μL
Pravastatin
Pitavastatin
Fluvastatin
Atorvastatin
Mevastatin
Lovastatin
Simvastatin
Column : Shodex ODP2 HP-2B (2.0mmI.D. x 50mm)
Eluent : (A); 10mM Ammonium formate aq.
(B); CH3CN
(B%) 10% (0min) -> 0% (3min) -> 5% (13min) -> 5% (20min)
Flow rate : 0.2mL/min
Detector : ESI-MS (SIM)
Column temp. : 40°C
