Copovidone is co-polymer made by N-vinyl-2- pyrolidone and vinyl acetate. It is used for coating agent or binder. Copovidone is insoluble in water, so dimethyl formamide (DMF) was used as the eluent. In this application, Even though DMF is used as the eluent, adding lithium bromide into the eluent is effective. Lithium bromide was added for analyzing copovidone.
Sample : 100µL
Poly(1-vinylpyrrolidone-co-vinyl acetate) 0.1% each
Copolymer 7:3
Copolymer 3:7
Columns : Shodex OHpak SB-806M HQ (8.0mmI.D. x 300mm) x 2 Eluent : 20mM LiBr in DMF Flow rate : 1.0mL/min Detector : Shodex RI Column temp. : 40°C
