Meet the Shodex Team at Booth 1117
We are pleased to have a booth and poster (Session Number: PS-P106) at Pittcon 2026 in San Antonio. Please stop by and see our newest columns, latest applications (all industries). Learn more about our upcoming poster presentation on analysis of extracellular vesicles using our new UB-100 column. Most importantly, qualify for a special up to 15% discount off your next column and/or standards kit purchase. Keep reading below for our Tuesday poster presentation details.
Team Members
Ron Benson (General Manager), Marlon Rettis (Manager, Latin America & US Sales), Tanya Napolitano (Technical & Marketing Manager), Alex Schrum (Manager, US Sales)
Poster Abstract
A simple, efficient, and robust process-analysis approach for the characterization of extracellular vesicles (EVs) was evaluated using the recently developed size-exclusion chromatography (SEC) column, Shodex UB-100, in combination with multiple detection technique. EVs hold potential as a novel therapeutic modality, which necessitates analytical methods for ensuring quality and process control for practical applications. However, simple techniques to assess sample-preparation reproducibility and to evaluate the impact of process changes or improvements remain underdeveloped.
In this study, we demonstrate the EV evaluation using Shodex UB-100 having an appropriate fractionation range for bio-nanoparticles including EVs, combined with multi-detector analysis (UV, fluorescence, and multi-angle light scattering (MALS) detectors). EV samples were prepared from conditioned medium of adipose-derived mesenchymal stem cells. Their purity in the steps of ultrafiltration and affinity purification were monitored using the developed method.
The UB-100 provided accurate assessment of sample condition and actionable guidance for improving purity and purification efficiency. The UB-100 offers high resolution with low back pressure, and its alkali resistance enables cleaning and continuous use, facilitating an easy transition from analytical to preparative purification processes.
In this study, we demonstrate the EV evaluation using Shodex UB-100 having an appropriate fractionation range for bio-nanoparticles including EVs, combined with multi-detector analysis (UV, fluorescence, and multi-angle light scattering (MALS) detectors). EV samples were prepared from conditioned medium of adipose-derived mesenchymal stem cells. Their purity in the steps of ultrafiltration and affinity purification were monitored using the developed method.
The UB-100 provided accurate assessment of sample condition and actionable guidance for improving purity and purification efficiency. The UB-100 offers high resolution with low back pressure, and its alkali resistance enables cleaning and continuous use, facilitating an easy transition from analytical to preparative purification processes.
Schedule
Day/Time
Tuesday, March 10, 2026 12:00 PM to 2:00 PM · 2 hr. (Central Standard Time)
Session Number: PS-P106
Section: Pharmaceutical & Biologics
Application: Life Sciences
Methodology: Process Analytical Techniques
Primary Focus: Methodology (HPLC)
Presenter
Tanya Napolitano
Poster Co-Authors
Masaru Watanabe, Hirobumi Aoki, Yuzuru Kokido – Resonac Corporation
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