Shodex Column Equivalent for Optima GPC Clean-Up Applications

Record: 607

Category: Column Selection
Product: EV-2000 AC
Sample: Pesticides

Question

Are you familiar with the Optima GPC column (cat. #624-123) from OI Analytical? If so, is there a Shodex equivalent?

Answer

The Optima GPC column from OI Analytical is commonly used as a GPC clean-up column in sample preparation workflows, particularly for the removal of high–molecular-weight matrix components prior to pesticide or residue analysis.

Shodex offers equivalent GPC clean-up solutions in the EV series, specifically Shodex EV-2000 and Shodex EV-2000 AC. These columns are designed for matrix clean-up applications, rather than analytical molecular-weight determination, and are widely used in food and environmental testing workflows.

Among these options, EV-2000 AC is especially suitable for pesticide residue clean-up, as it effectively excludes high–molecular-weight interferences while allowing target pesticide compounds to elute under compatible solvent conditions. Many analytes typically processed using Optima GPC columns fall within the applicable clean-up range of EV-2000 AC.

Final column selection should be based on the target analytes, sample matrix, and eluent system used in the method.

Recommended Application:

GPC Clean-Up of Pesticide Residues Using EV-2000 AC

This application demonstrates the use of Shodex EV-2000 AC as a GPC clean-up column for pesticide residue analysis. The column is used to remove high–molecular-weight matrix components while allowing pesticide analytes to elute, supporting efficient downstream analysis.

This workflow reflects the typical use case of Optima GPC columns in pesticide and residue clean-up methods.

GPC clean-up columns are selected based on matrix removal performance and solvent compatibility, rather than precise molecular-weight separation. If the customer can provide a list of target compounds and mobile phase conditions, Shodex Technical Support at support@shodexhplc.com can confirm whether EV-2000 or EV-2000 AC is the most appropriate equivalent.

Additional Comments

Download or Print PDF