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DMSO Compatibility of SB vs. LB Series Columns

Record: 924


Category: Column Selection
Product: SB and LB
Sample: N/A


Question
Which SB columns are compatible with DMSO, and why is the LB series not?

Answer

  • SB-802.5 HQ, SB-803 HQ, SB-804 HQ, SB-805 HQ, SB-806 HQ, SB-806M HQ → Compatible with up to 100% DMSO (recommended at 50–70 °C).

  • SB-802 HQ & SB-807 HQ → Not DMSO compatible.

The LB-800 series is also not compatible with DMSO. While it accepts ACN, MeOH, and DMF (up to 100%), DMSO is excluded because the LB columns are surface-treated to minimize baseline noise for light scattering detectors. This treatment reduces solvent tolerance and makes the packing unstable in highly viscous solvents like DMSO.

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