Featured columns include our HILIC, Ion Chromatography and polymer reversed phase columns. Please browse through our VN series HILIC columns especially designed for oligo-DNA and oligo-RNA. Moreover, we have a new line of polymer LB series columns for oligosaccharide separation. The LB series is highly uniform for higher plate count and best in class peak resolution.

Hydrophilic Interaction Liquid Chromatography (HILIC)

Discover the power of Hydrophilic Interaction Liquid Chromatography (HILIC) with our premium range of HILIC columns. Designed for superior separation of polar compounds, our HILIC columns offer unmatched performance and reliability for your analytical needs

Applications:

• Pharmaceutical Analysis: Efficiently separate and analyze polar drug compounds and metabolites
• Biotech Research: Ideal for studying phosphorylated compounds and metabolomics
• Food & Agriculture: Quantify Organic Acids, Sugars, and Vitamins with ease
• Environmental Testing: Excellent retention of polar pesticides like glyphosate and environmental contaminates like short-chain PFAS (ex. TFA)

HILIC Fundamentals

HILIC stands for Hydrophilic Interaction liquid Chromatography. In HILIC mode, a packing material with a highly polar surface is used, with typical functional groups such as amide groups, amino groups, and diol functional groups bonded to silica or polymer base materials. Typically, a polar solvent such as a mixture of water and acetonitrile is used as the eluent, with high a organic solvent ratio to water. Under these conditions, a hydration layer forms on the packing material surface. The analyte’s distribution between the packing material and eluent is influenced by their polarities, analytes are eluted in an order of higher polarity to lower polarity. In HILIC mode, in addition to partitioning, electrostatic interactions, hydrogen bonding, and van der Waals interactions work in a complex manner to achieve high selectivity. Learn more in our "Lesson 3: Separation Modes and their Mechanisms"

HILIC Series Overview

VG-50	Suitable for saccharide analysis using HILIC mode Recovers reducing saccharides with high ratio Polymer-based packing material provides excellent chemical stability and minimum deterioration over an extended time period Easily regenerated by washing in an alkaline solution Appropriate for evaporative light scattering detector, corona charged aerosol detector, and LC/MS
VT-50 2D	Suitable for anionic substances (especially phosphate compounds) analysis using HILIC mode Use of some eluents add ion exchange mode Polymer-based packing material provides excellent chemical stability and minimum deterioration over an extended time period Suitable for LC/MS analysis
VC-50 2D	Modified carboxyl group is suitable for cationic substance analysis including amines The dominant separation mode is RP or IEX rather than HILIC mode
VN-50	The modified diol groups on the packing material create the HILIC mode Suitable for oligonucleotide and oligosaccharide separation which is not possible by SEC or conventional HILIC columns VN-50 1D adopts a double structure housing with an outer surface made of SUS and an inner surface [wetted part] made of PEEK. Covers the weak point of physical strength of PEEK housing and can be used under high pressure conditions. VN-50 1D has an inner diameter of 1.0 mm, which makes it possible to suppress the flow rate to 0.1 mL/min or less, so it suitable for high sensitivity analysis by LC/MS.

Meeting Exact Requirements for USP HPLC Columns

Shodex provides precision-engineered, fully compliant USP HPLC columns that map directly and accurately to the official U.S. Pharmacopeia (USP) L-codes. With over 50 years of specialized expertise, we deliver consistent, highly durable analytical solutions specifically tailored for stringent pharmaceutical QC environments. Explore each USP L-code classification and the corresponding Shodex offerings.

Helping to Simplify Pharmaceutical HPLC Column Selection

Understanding USP L-classifications is paramount, as they dictate the precise packing materials required to execute official analytical methods in regulated industries. The challenge is identifying the precise HPLC column for complex USP method development. Shodex simplifies this process by providing a comprehensive guide that helps method developers and lab managers rapidly navigate USP L-classifications and identify the ideal column equivalent to a USP monograph with confidence. We offer highly specialized pharmacopeia HPLC columns, such as:

• USP L1 column: For general reversed-phase applications.
• USP L17 cation exchange: For efficient separation of basic compounds.
• USP L20 HILIC column: Size exclusion columns for biomolecules (e.g., proteins)
• USP L23 ion exchange column: USP L23: Ion exchange columns commonly used for inorganic anion analysis.
• Polymer-based USP L25 column: Size exclusion columns for water-soluble polymers.
• USP L58 protein analysis column: Size exclusion columns designed for protein analysis

Shodex USP Column Equivalency Guide

This resource details specific packing materials and provides clear guidance on selecting columns that meet your analytical and regulatory needs. Click on the L# on the left to view and compare the columns in that category.

No.	Packing material	Recommended column
L1	Octadecyl silane chemically bonded to porous or nonporous silica or ceramic microparticles, 1.5 to 10 μm in diameter, or a monolithic rod.	C18 Silica C18M C18U
L17	Strong cation-exchange resin consisting of sulfonated cross-linked styrene-divinylbenzene copolymer in the hydrogen form, 6 to 12 μm in diameter.	SUGAR SH1011 SUGAR SH1821 RSpak KC-811
L19	Strong cation-exchange resin consisting of sulfonated cross-linked styrene-divinylbenzene copolymer in the calcium form, 5-15 μm in diameter.	SUGAR SC1011 SUGAR SC1211 EP SC1011-7F USPpak MN-431
L20	Dihydroxypropane groups chemically bonded to porous silica or hybrid particles, 1.5-10 μm in diameter, or a monolithic silica rod.	PROTEIN KW-800 series KW400 series PROTEIN LW-803 PROTEIN LW-403 4D
L21	A rigid, spherical styrenedivinylbenzene copolymer, 3 to 30 μm in diameter.	GPC KF-800, KD-800, KF-400HQ, HK-400, LF, RSpak DS-613 RSpak DS-413
L22	A cation-exchange resin made of porous polystyrene gel with sulfonic acid groups, 5-15 μm in diameter.	CXpak P-421S SUGAR SP0810 SUGAR SC1011 SUGAR KS-800 series SUGAR SC1211 SUGAR SZ5532 EP SC1011-7F USPpak MN-431 RSpak DC-613 SUGAR SH1011 SUGAR SH1821 RSpak KC-811
L23	An anion-exchange resin made of porous polymethacrylate or polyacrylate gel with quartenary ammonium groups, 7-12 μm in size.	IEC QA-825 IC I-524A
L25	Packing having the capacity to separate compounds with a molecular weight range from 100-5000 (as determined by polyethylene oxide), applied to neutral, anionic, and cationic water-soluble polymers. A polymethacrylate resin base, cross-linked with polyhydroxylated ether (surface contained some residual carboxyl functional groups) was found suitable.	OHpak SB-802 HQ OHpak SB-802.5 HQ OHpak LB-802.5
L33	Packing having the capacity to separate dextrans by molecular size over a range of 4,000 to 500,000 Da. It is spherical, silica-based, and processed to provide pH stability.	PROTEIN KW-800 series KW400 series PROTEIN LW-803 PROTEIN LW-403 4D
L34	Strong cation-exchange resin consisting of sulfonated cross-linked styrene-divinylbenzene copolymer in the lead form, 7 to 9 μm in diameter.	SUGAR SP0810
L37	Packing having the capacity to separate proteins by molecular size over a range of 2,000 to 40,000 Da. It is a polymethacrylate gel.	OHpak SB-803 HQ OHpak LB-803
L38	A methacrylate-based size-exclusion packing for water-soluble samples.	OHpak SB-800 HQ series OHpak LB-800 series
L39	A hydrophilic polyhydroxymethacrylate gel of totally porous spherical resin.	ODP2 HP RSpak DM-614 OHpak SB-800 HQ series OHpak LB-800 series
L45	Beta cyclodextrin, R,S-hydroxypropyl ether derivative, bonded to porous silica particles, 3-10 μm in diameter.	ORpak CDBS-453
L58	Strong cation-exchange resin consisting of sulfonated cross-linked styrene-divinylbenzene copolymer in the sodium form, about 6 to 30 μm in diameter.	CXpak P-421S SUGAR KS-800 series RSpak DC-613
L59	Packing for the size-exclusion separations of proteins (separation by molecular weight) over the range of 5 to 7000 kDa. The packing is a spherical 1.5- to 10-μm, silica or hybrid packing with a hydrophilic coating.	PROTEIN KW-800 series KW400 series PROTEIN LW-803 PROTEIN LW-403 4D
L67	Porous vinyl alcohol copolymer with a C18 alkyl group attached to the hydroxyl group of the polymer, 2 to 10 μm in diameter.	Asahipak ODP-50
L71	A rigid, spherical polymetacrylate, 4 to 6 μm in diameter.	RSpak DE-613 RSpak DE-413 RSpak DE-213
L76	Silica based, weak cation-exchange material, 5 μm in diameter. Substrate is surface polymerized polybutadiene-maleic acid to provide carboxylic acid functionalities. Capacity not less than 29 μEq/column.	IC YK-421
L82	Polyamine chemically bonded to cross-linked polyvinyl alcohol polymer, 5 μm in diameter.	Asahipak NH2P-50
L89	Packing having the capacity to separate compounds with a molecular weight range from 100 to 3000 (as determined by polyethylene oxide), applied to neutral and anionic water-soluble polymers. A polymethacrylate resin base, cross-linked with polyhydroxylate ether (surface contains some residual cationic functional groups).	OHpak SB-802.5 HQ OHpak LB-802.5

Why Trust Shodex for Analytical Excellence

Shodex has been a trusted partner in analytical science since 1973, delivering unparalleled expertise in chromatographic solutions. Our commitment to innovation and precision is reflected in every product, offering research professionals the confidence needed to meet stringent analytical demands. Our foundation of excellence is evident in our commitment to:

• Regulatory compliance: We reassure users that Shodex products fully support method adjustments in accordance with USP <621> guidelines
• Method development: Our robust packing materials guarantee reproducible, reliable results during rigorous method development and routine chromatographic assays.
• Polymer-based expertise: Shodex’s unique polymer advantage offers superior chemical stability, extended column lifespan and precise separation for complex pharmaceutical QC column selection compared to traditional silica materials.
• Global reliability: Our products are manufactured in Japan to the highest quality standards, for batch-to-batch consistency essential in regulated laboratories.

Connect With the Technical Experts at Shodex

Identifying the correct USP L-code is only the beginning. Achieving complex analytical goals requires responsive, specialized vendor support. Shodex offers unparalleled technical expertise to streamline your USP method column selection process. Complete our contact form to consult directly with Shodex technical specialists and learn more about our 30-day trials, which let you confidently verify column suitability for your specific regulatory applications with zero risk.

 

Shodex™ ligand exchange, ion exclusion, and specialized GFC columns support the separation of carbohydrates ranging from monosaccharides and disaccharides to oligosaccharides and polysaccharides. Moreover, we offer columns that can separate both organic acids and saccharides simultaneously. Depending on the column chemistry and mobile phase, Shodex columns separate analytes through ligand exchange, ion exclusion, or mixed-mode mechanisms. For example, the KS series combines ligand exchange and size exclusion mechanisms for carbohydrate separations. Read more about the features below, as well as our column selection guide. Choose the correct column or columns for your application. Please refer to our HILIC and Gel Filtration product guides for more information about saccharides and organic separations in other modes.

SC1011	Separates saccharides by a combination of ligand exchange and size exclusion mechanisms. Fulfills USP-NF L19 and L22 requirements.
SP0810	Available with Ca²⁺, Pb²⁺, or Na⁺ counter ions. Fulfills USP-NF L22 and L34 requirements.
KS-801	Neutral sugar analysis using water as the mobile phase. Fulfills USP-NF L22 and L58 requirements.
KS-802	Suitable for oligosaccharide separations. Fulfills USP-NF L22 and L58 requirements.
KS-803	Designed for oligosaccharide separations using size exclusion chromatography.
KS-804	Can be connected in series with KS-801 and/or KS-802 for extended separation range. Water can be used as the mobile phase for neutral sugar analysis. Fulfills USP-NF L22 and L58 requirements.
DC-613	Separates sugars using a combination of ligand exchange and HILIC mechanisms. Allows sugar analysis without prior removal of sodium salts from the sample. Fulfills USP-NF L22 and L58 requirements.
SZ5532	Recommended for separation of disaccharides and trisaccharides. Fulfills USP-NF L22 requirements.
SC1211	Suitable for separation of sugar alcohols. Fulfills USP-NF L19 and L22 requirements.
SC1011-7F	Pharmacopoeia method-relevant Ca²⁺-modified ligand exchange chromatography column.
MN-431	Neutral sugar analysis using water as the mobile phase. Fulfills USP-NF L19 and L22 requirements.

Column Selection: by Combination of Saccharides

Saccharides to be separated	Columns to be selected
Monosaccharides
Glu,Fru	SP0810,SC1011,SC1211,KS-801
Glc,Gal,Fru	SP0810,SC1011,SC1211
Glc,Gal,Man	SP0810
Glc,Gal,Ara	SP0810,SC1011,SZ5532
Glc,Xyl,Ara	SP0810,SC1011,SZ5532
Glc,Fru,Sorbitol	SC1011,SC1211,SC1821 (discontinued),SZ5532
Glc,Gal,Sorbitol,Ducitol	SP0810,SC1011
Glc,Gal,Man,Sorbitol,Ducitol,Mannitol	SP0810
Glc,Fru,Gly,EtOH	SC1011,SC1211,KS-801
Glc,Fru+alcohols	SC1011,SH1011,SC1211
Glc,Fru+organic acids	SH1011,SH1821
Disaccharides
Suc,Lac	SZ5532
Suc,Mal	SZ5532
Suc,Mal,Lac	SZ5532
Mal,Isomaltose	SZ5532
Lac,Lactulose	SP0810,SC1011
Suc,Glc,Fru	SC1011,SC1211,KS-801,SZ5532
Suc,Lac,Glc,Gal,Fru	SZ5532
Mal,Glc,Fru,Gly,EtOH	SC1011,SC1211,KS-801
Cel,Glc,Gal,Man,Xyl,Ara	SP0810
Mal,Glc,Fru,Sorbitol	SP0810,SC1011,SC1211,SZ5532
Mal,Glc,Fru+alcohols	SC1011,SC1211,SH1011
Mal,Glc,Fru+organic acids	SH1011,SH1821
Suc,Glc,Fru,Sorbitol	SP0810,SC1011,SC1211,SC1821
Mal,Maltitol	SP0810,SC1011,SC1211,SZ5532
Suc,Lac,Mal,Maltitol	SZ5532
Glc,Suc,Erythrytol	SP0810,SC1011,KS-801
Mal,Glc,Fru,Erythrytol	SP0810,SC1011
Sta,Raf,Mal,Glc,Gal,Ara	SC1011,KS-801,SZ5532
G4,G3,Mal,Glc	SC1011,KS-801,KS-802
Sta,Raf,Suc,Glc	SC1011,KS-801,SZ5532
Raf,Suc,Glc,Fru,Ara	KS-801
Maltooligosaccharide	SC1821 (discontinued),KS-802,SZ5532
Maltooligosaccharide+alcohols	SC1821 (discontinued),KS-802,SH1821
Maltooligosaccharide+organic acids	SH1821
Maltooligosaccharide+sugar alcohols	SC1821 (discontinued),SC1011+KS-802
Xylitol,Sorbitol	SC1011,SC1211,SZ5532
Sobitol,Mannitol,Xylitol	SP0810,SC1211,SZ5532
Sobitol,Dulcitol,Xylitol	SP0810,SC1011,SZ5532
Maltitol,Sorbitol	SC1011,SC1211,SZ5532
Maltitol,Dulcitol,Arabitol,Xylitol,Mannitol,Sorbitol	SC1211

Innovative Solutions for Your Laboratory

Shodex polymer-based columns, including ligand exchange, ion exclusion and select GFC columns, are engineered for durable performance within specified operating windows. Select polymer-based columns support wide pH operating ranges (up to pH 2–13); refer to individual column specifications for operating limits. For specific pH, solvent, temperature or counterion compatibility, always refer to the individual column datasheet. Shodex ligand exchange HPLC columns are optimized for the separation of select small, polar molecules — most commonly sugars, but also applicable to amino acids, depending on the model. The SUGAR column series is designed for high-resolution separation and quantification of mono- and disaccharides and can support oligosaccharide analysis in many food and beverage samples. For particularly complex matrices or high-oligosaccharide content, performance may depend on application-specific optimization. Shodex GFC saccharide columns separate carbohydrates according to hydrodynamic size using size exclusion mechanisms. Shodex has developed the proprietary RSpak KC-811 column, a polymer-based organic acid column that operates primarily by ion exclusion with secondary reversed-phase interactions for separation and quantification of organic acids across various matrices. Since it is a polymer-based column, it offers high chemical stability.

Support for Regulated Methods

While results and lifespan can vary, Shodex columns are designed for consistent separation, supporting confidence in saccharide analysis HPLC data, as well as long-term performance. Many Shodex columns are suitable for use with organic acid ion exclusion, ligand exchange, sugar separation and regulated methods and are referenced in official compendia such as USP-NF and others. Users should verify that their chosen column is validated for the specific regulatory method required. Learn more about the products and their applications in our detailed technical notes database.

Why Trust Us?

We have a deep focus on polymer-based and specialized separations, which has allowed us to develop unique products since 1973. Our technical team has decades of experience addressing analytical challenges, reflected in their extensive technical notes and support resources. With more than 1,000 products, including specialized columns, our team at Shodex is a comprehensive provider for a range of analytical needs. We have a deep commitment to education, with expert guidance to help you find the dedicated, high-performing column right for your application. Our portfolio includes columns developed to align with common pharmacopoeial requirements, supporting reliable results when following established industry methods. Please consult product documentation to confirm suitability.

Contact Shodex for the Right Column

With robust technical support and application guidance, both before and after your purchase, our team at Shodex HPLC is your partner for a range of analysis needs. Contact us with your sales and technical questions.

High-Performance SEC Columns for Polymer and Protein Analysis

Researchers in polymer molecular weight analysis and biopharmaceutical characterization need precise, reproducible data for macromolecules and oligomers. Achieving accurate molecular weight and distribution requires size exclusion chromatography columns that deliver reliable performance. Shodex™ SEC columns directly meet these analytical demands, offering specialized solutions for superior stability and selectivity. Our decades of expertise simplify your SEC challenges, providing consistent, high-performance products that let you confidently advance your macromolecule and oligomer analysis. Shodex SEC HPLC columns (Size Exclusion Chromatography, also called GPC or Gel Permeation Chromatography) deliver precise molecular weight analysis for polymers, proteins, and macromolecules. Our polymer-based columns provide exceptional resolution from small oligomers to multi-million dalton polymers, with superior pH stability (2-13) for long-term reliability. Popular applications include protein aggregation testing, antibody characterization, polymer molecular weight distribution, and natural polymer analysis. Choose aqueous SEC columns (PROTEIN KW, OHpak SB) for proteins and water-soluble polymers, or organic GPC columns (KF-800, GPC LF) for synthetic polymers in THF or chloroform. Need help selecting the right SEC HPLC column for your application? Contact our technical team for expert method development support.

Characteristics of   Size Exclusion Chromatography
Network of pores on the surface of the packing material works as molecular sieve to separate molecules based on hydrodynamic size.
To separate molecules solely based on hydrodynamic size (molecular size in solution), it requires an analytical condition that prevents interactions between compounds and packing gel.
The bigger the molecule size, the faster the elution sequence.
Used for molecular weight or molecular distribution determination of macromolecules and characterization of oligomers.
SEC is a non-interactive separation technique; minimizing interactions between analytes and the stationary phase is critical for accurate molecular weight determination.

Specialized SEC Columns for Every Application

Shodex offers size exclusion chromatography columns tailored to meet the diverse needs of modern analytical laboratories, helping researchers identify the optimal solution for their specific soluble samples.

Gel Filtration Chromatography (GFC)

Our GFC columns are specifically engineered to separate water-soluble samples by size, making them ideal for aqueous SEC columns. Choose from our durable polymer-based GFC or specialized silica-based GFC options. These silica-based columns excel in applications such as protein SEC columns and precise monoclonal antibody SEC analysis, providing high-resolution separations for complex biological mixtures and ensuring the reproducibility critical for biopharmaceutical characterization.  Our polymer based GFC column excel with accurate moleclar wieght determination of polar polymers like polysaccharides.

Gel Permeation Chromatography Columns (GPC)

For laboratories working with organic-soluble samples, our GPC columns provide robust solutions. Compatible with solvents like THF, DMF, and Chloroform, our organic GPC columns are well-suited for analyzing the molecular weights of complex polymers, delivering reliable data for both synthetic and natural polymers.

Multimode and Multi-solvent GPC

Shodex's versatile multimode and multi-solvent GPC offerings are designed to handle a broader range of challenging samples with multiple solvent options for flexible polymer analysis. These GPC columns provide exceptional flexibility and efficiency for complex analyses where a single solvent system is insufficient.

Why Trust Our Chromatography Solutions?

Shodex stands apart by combining material durability, expertise and superior logistics, addressing the critical needs of analytical laboratories and quality control departments. Benefits of working with us include:

• Polymer-based durability: Shodex specializes in polymer-based GFC and GPC columns, offering superior long-term durability, extended column lifespan and exceptional cost-effectiveness compared to generic silica alternatives.
• Decades of SEC specialization: We are a deeply specialized pioneer with over five decades of expertise in SEC columns, backed by vast, publicly accessible methodologies.
• Logistical expertise: Benefit from fast delivery and local expert support for your molecular weight analysis needs anywhere in the Americas.

Upgrade Your Analytical Capabilities With Shodex

Experience the benefits of durable, cost-effective SEC columns backed by direct logistical support and a legacy of polymer expertise. Browse our specific product categories above, or contact the Shodex technical team for recommendations on custom SEC columns.

Suppressor and Non-Suppressor Systems for Rapid Analysis

Analytical laboratories frequently encounter challenges with silica-based ion chromatography columns degrading rapidly under extreme pH conditions, compromising data integrity for critical anion and cation exchange methods. Shodex addresses this directly with advanced polymer-based IC columns, engineered for exceptional durability and high performance. These robust systems achieve reliable lot-to-lot consistency, delivering superior pH stability and chemical stability crucial for complex sample matrices, including precise analysis of oxyhalides and inorganic ions. Shodex™ ion chromatography columns are among the best in the industry. Refer to the features for each column and the column selection guide below to learn more about our products.

Optimized Systems for Diverse IC Applications

To meet the varied demands of modern analytical laboratories, we offer both suppressed columns for sensitive anion separations required for water analyses and non-suppressed columns that can be run on traditional HPLC systems equipped with a conductivity detector. Each is precisely engineered to deliver the performance required for specific applications, ensuring efficient and reliable anion analysis or cation analysis.

Suppressor IC Columns for High-Sensitivity Analysis

Shodex suppressor IC columns are designed for ultra-sensitive conductivity detection of trace inorganic anions. Features include:

• Compatibility with challenging alkaline conditions, such as sodium carbonate eluent and potassium hydroxide (KOH) eluent
• Rapid oxyhalide analysis IC, as well as quantifying trace fluoride, chloride, nitrate, sulfate and phosphate
• Support for demanding IC columns for water testing methods like EPA 300 ion chromatography

Non-Suppressor IC Columns for Standard HPLC Systems

For laboratories requiring accessible and versatile solutions, Shodex non-suppressor IC columns integrate seamlessly into standard HPLC systems. Features include:

• No additional suppressor hardware required.
• Efficient separation of inorganic anions from organic acids in anion chromatography columns
• Ideal for rapid analysis and cost-effectiveness

Column	Feature / Description
NI-424	Non-suppressor anion column for general inorganic ions. Provides improved separation of fluoride and phosphate ions compared with I-524A.
I-524A	Non-suppressor anion column for routine analysis using a conventional HPLC system with conductivity detection. Fulfills USP-NF L23 requirements.
SI-90 4E	Suppressor-type anion column for general inorganic ion analysis using carbonate-based eluents. Suitable for EPA Method 300.1(A) applications.
SI-50 4E	High-resolution suppressor-type column for general inorganic anions, including fluoride. Useful for complex samples containing organic acids.
SI-52 4E	Suppressor-type column designed for simultaneous analysis of oxyhalides and general inorganic anions using carbonate-based eluents. Suitable for EPA Method 300.1(B) applications.
SI-35 4D	Rapid-analysis suppressor-type column for oxyhalides and general inorganic anions using carbonate-based eluents.
SI-35 2B	Short suppressor-type column for rapid analysis of general inorganic anions using carbonate-based eluents.
SI-36 4D	Suppressor-type anion column compatible with potassium hydroxide eluents. Provides improved selectivity for sulfite and sulfate and can separate seven common inorganic anions under isocratic conditions.

Polymer-Based Advantages: Unmatched Performance for Regulated Applications

Shodex's polymer-based technology offers distinct advantages for laboratories operating under stringent regulatory scrutiny:

• Environmental compliance: Achieve reliable results for environmental water testing and drinking water analysis, with columns meeting EPA 300 method requirements for accurate and reproducible data.
• Pharmaceutical quality control: Align with stringent pharmaceutical QC standards, including USP-NF L23 requirements, through columns designed for exceptional stability and reproducibility over thousands of uses.
• Operational efficiency: Benefit from the extended lifetime and superior lot-to-lot consistency of polymer-based materials, which significantly reduce column replacement frequency and overall laboratory costs.

Why Trust Shodex for Ion Chromatography?

Shodex brings over 50 years of pioneering experience in specialized polymer-based chromatography technologies, serving advanced analytical laboratories worldwide. Our dedicated expert support team is available to assist with method development and optimal IC column selection.

Optimize Your Ion Chromatography Results With Shodex

Upgrade your analytical methods with durable polymer-based ion chromatography columns. Reach out today to request a quote or to receive personalized assistance selecting the optimal column for your specific application.

ODP-50 C4P-50 4D	Relatively large pore size is suitable for the analysis of amino acids, peptides, and proteins Usable in a wide pH range from pH 2 to 13Usable in 100% water and buffer solution Best used for the analysis of basic substancesODP-50 fulfills USP-NF L67 requirements
ODP2 HP	Provides a large theoretical plate number nearly twice as much as generally available polymer-based reversed phase columns do Offers enhanced retention of high polar substances compared to ODS columns Suitable for the analysis of small molecules such as pharmaceuticals in the presence of protein matrix Ideal for LC/MS analysis of high polar compoundsFulfills USP-NF L39 requirements
DS-613 DS-413	Suitable for reversed phase analysis of highly hydrophilic substances, that are not well retained by ODS columns Fulfills USP-NF L21 requirements
DE-613 DE-413 DE-213	General purpose polymer-based column having similar polarity as ODS columns Wide working pH range (from pH 2 to 12), usable in 100 % water and buffer solutions Fulfills USP-NF L71 requirements
DM-614	Suitable for the analysis of amino acids and water-soluble vitamins Fulfills USP-NF L39 requirements
NN-814	The packing material modified with sulfo groups supports multimode (reversed phase and cation exchange) analysis Ideal for the analysis of complex samples containing neutral and ionic substances
JJ-50 2D	The packing material is modified with trace amounts of quaternary ammonium groups, and supports multimode (reversed phase and anion exchange) analysis Ideal for analysis of complex samples containing neutral and ionic substances

C18U	ODS columns for UHPLC (Maximum pressure: 100 MPa) Achieves high performance analysis with sub-2 μm particles Organic/inorganic silica hybrid particles provide excellent resolution and mechanical stability and improved alkali durability (from pH 1 to 12) Usable in 100 % water and buffer solution Fulfills USP-NF L1 requirements